Intra-tumor genetic heterogeneity in Wilms tumor samples
نویسندگان
چکیده
منابع مشابه
Intra-Tumor Genetic Heterogeneity in Wilms Tumor: Clonal Evolution and Clinical Implications
The evolution of pediatric solid tumors is poorly understood. There is conflicting evidence of intra-tumor genetic homogeneity vs. heterogeneity (ITGH) in a small number of studies in pediatric solid tumors. A number of copy number aberrations (CNA) are proposed as prognostic biomarkers to stratify patients, for example 1q+ in Wilms tumor (WT); current clinical trials use only one sample per tu...
متن کاملEvidence for genetic heterogeneity in familial Wilms' tumor.
Wilms' tumor (WT), a childhood kidney cancer, occurs both sporadically and, less frequently, in a familial context. Genetic linkage studies of several large WT families have excluded the one cloned WT gene, WT1, as the locus responsible for familial predisposition. These data demonstrate the existence of a familial predisposition gene distinct from WT1 and, more broadly, imply that the genetic ...
متن کاملMiR-21 Expression in Wilms’ Tumor
Background and Objective: Wilms’ tumor (WT) is the most common genitourinary tract tumor in children. MicroRNAs (miRNAs) are small non-coding RNAs; their role in the pathogenesis of many types of human cancers has been identified. We aimed to evaluate the expression of miR-21, a well-known oncomir, in WT tissue samples which is a very common urinary tract malignancy in children...
متن کاملGenetic Predisposition to Wilms Tumor
Wilms tumor is a primarily sporadic disease, with only 1–2 % of affected individuals having a relative with Wilms tumor. However, bilateral Wilms tumors occur in approximately 5 % of cases, and Wilms tumor has been reported in association with more than 50 different genetic disorders, pointing to an underlying predisposition in further individuals. There is conclusive evidence of an increased r...
متن کاملMalformations, genetic abnormalities, and Wilms tumor.
BACKGROUND Wilms Tumor (WT) can occur in association with tumor predisposition syndromes and/or with clinical malformations. These associations have not been fully characterized at a clinical and molecular genetic level. This study aims to describe clinical malformations, genetic abnormalities, and tumor predisposition syndromes in patients with WT and to propose guidelines regarding indication...
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ژورنال
عنوان ژورنال: Revista da Associação Médica Brasileira
سال: 2019
ISSN: 1806-9282,0104-4230
DOI: 10.1590/1806-9282.65.12.1496